Tag Archives: ra research briefs

eating fish rheumatoid arthritis

RA Research Briefs: Tofacitinib, Fish, Remission

Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries.

Tofacitinib Plus Methotrexate May Work As Well As Biologic

If methotrexate (MTX) alone fails to control RA, adding the oral Janus kinase (JAX) inhibitor tofacitinib (Xeljanz) may be as effective as the standard practice of adding a biologic. The JAX inhibitor belongs to the third category of disease-modifying antirheumatic drugs (DMARDs) called targeted DMARDs. In a study of 1,146 patients with rheumatoid arthritis that had not adequately responded to MTX alone, approximately a third were switched to tofacitinib, while the others received either tofacitinib or the biologic adalimumab (Humira) along with methotrexate. At 6 months, only 38% of the patients receiving tofacitinib mono­therapy achieved ACR50 – 50 percent improvement – while 46% of patients that received tofacitinib and MTX achieved that response. Forty-four percent of patients who combined adalimubab with MTX achieved the similar improved response of the tofacitnib and MTX group.

SOURCE: The Lancet, July 2017  Continue reading RA Research Briefs: Tofacitinib, Fish, Remission

rheumatoid arthritis research briefs remission exercise

RA Research Briefs: Remission, Biologics, Exercise

Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries.

Smoking, Obesity Make RA Harder to Control

Remission in RA patients can be harder to achieve in those who are overweight or smoke, according to a recent study. American and Canadian researchers who collected data on more than 1,100 patients receiving standard treatment for RA found that sex (being female), excess weight and smoking were not significantly associated with symptom severity early on. However, all three factors influenced how much symptoms improved over time. The most dramatic differences in symptoms were seen in patients who were overweight or obese and smoked, the study found.

Source: ACR/ARHP Annual Meeting, November 2016

Continue reading RA Research Briefs: Remission, Biologics, Exercise

rheumatoid arthritis green tea

RA Research Briefs: Remission, Surgery, Green Tea

Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries.

Obesity Reduces Odds of RA Remission

Research suggests weight may be a factor in whether people with RA will achieve disease remission. A review of studies screened a total 3,368 patient records. Canadian researchers found obese patients with RA were less likely to achieve remission or sustain remission compared to healthy-weight patients. Obesity, they reported, negatively impacts disease activity and patient-reported outcomes during therapy. Therefore, they say, interventions to reduce BMI should be investigated for the ability to improve disease outcomes.

Source: Arthritis Care & Research, January 2017

Continue reading RA Research Briefs: Remission, Surgery, Green Tea

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Rheumatoid Arthritis Research Briefs: RA Tests, Dementia, Disability

Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries.

Obesity May Affect RA Tests

Research has shown that obesity can increase the risk of RA or worsen symptoms. A new study of more than 2,000 people with RA suggests it could also affect the results of tests used to measure RA inflammation.

Researchers at the University of Pennsylvania found a link between body mass index (BMI, a measure of body fat) and elevated results of two common tests – SED rate and C-reactive protein (CRP) – used in diagnosing RA and gauging its activity. Researchers say this association is related to fat mass and not RA disease activity. Doctors should consider a patient’s BMI when interpreting lab results.

Source: Arthritis Care & Research, published online April, 2017

Continue reading Rheumatoid Arthritis Research Briefs: RA Tests, Dementia, Disability