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eating fish rheumatoid arthritis

RA Research Briefs: Tofacitinib, Fish, Remission

Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries.

Tofacitinib Plus Methotrexate May Work As Well As Biologic

If methotrexate (MTX) alone fails to control RA, adding the oral Janus kinase (JAX) inhibitor tofacitinib (Xeljanz) may be as effective as the standard practice of adding a biologic. The JAX inhibitor belongs to the third category of disease-modifying antirheumatic drugs (DMARDs) called targeted DMARDs. In a study of 1,146 patients with rheumatoid arthritis that had not adequately responded to MTX alone, approximately a third were switched to tofacitinib, while the others received either tofacitinib or the biologic adalimumab (Humira) along with methotrexate. At 6 months, only 38% of the patients receiving tofacitinib mono­therapy achieved ACR50 – 50 percent improvement – while 46% of patients that received tofacitinib and MTX achieved that response. Forty-four percent of patients who combined adalimubab with MTX achieved the similar improved response of the tofacitnib and MTX group.

SOURCE: The Lancet, July 2017  Continue reading RA Research Briefs: Tofacitinib, Fish, Remission

Rheumatoid Arthritis Outcomes Lifestyle

Outlook Brighter For People With Rheumatoid Arthritis

People with rheumatoid arthritis (RA) are likely to have a much better quality of life today than they did two decades ago. Researchers in the Netherlands observed more than 1,100 patients diagnosed with RA between 1990 and 2011. They attribute the gains to earlier diagnosis, more aggressive medications and a greater emphasis on overall well-being. Their findings were published in Arthritis Care & Research in 2014.

Lead author Cecile Overman, a postdoctoral researcher at Utrecht University in the Netherlands, says she and her colleagues wanted to determine if improved treatments over the last 20 years led to better physical and psychological health for RA patients. Continue reading Outlook Brighter For People With Rheumatoid Arthritis