Biologics Rheumatoid Arthritis Cancer

Biologics Appear Safe for Some Rheumatoid Arthritis Patients Who’ve Had Cancer

Researchers set out to answer a pressing question: Is it safe for rheumatoid arthritis (RA) patients who have had cancer in the past to use a biologic drug rather than a traditional disease-modifying antirheumatic drug (DMARD), like methotrexate, to control their disease? Their answer, detailed in a study recently published online in the journal Rheumatology, is reassuring. They found that patients with a previous malignancy who later took certain biologics did not appear to have an increased risk of cancer after an average of five years, compared to those who took a traditional DMARD.
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Anti TNF RA Flare

Study: Risk of Rheumatoid Arthritis Flare Triples in People Who Stop Anti-TNFs

Biologic drugs make it possible for many people with inflammatory types of arthritis, such as rheumatoid arthritis (RA), to achieve low disease activity or remission. But because of the drugs’ cost and the potential for serious side effects, many patients don’t want to stay on them indefinitely, so researchers have been looking at whether it’s possible to taper or stop them. A new study, published recently in Arthritis & Rheumatology, is adding to the growing body of research on the topic.
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Track React Rheumatoid Arthritis Tracking Tool

Announcing the New and Improved Rheumatoid Arthritis Track + React App!

Track what you do and how you feel on a daily basis – even when you’re on the go! The newly relaunched Track + React app can be used as a web tool on arthritis.org as well as on your smartphone via the app. Track + React features a completely revamped free mobile app available for download for iPhone and Android devices that allows you to track key daily activities related to your rheumatoid arthritis (RA) wherever you are.
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Fatigue Rheumatoid Arthritis

Study Shows Fatigue Persists in Some Cases Even When Rheumatoid Arthritis Is Controlled

The fatigue that often accompanies rheumatoid arthritis (RA) can be as distressing and disabling as the pain – and often harder to treat. RA-related fatigue has been associated with molecules called cytokines that promote inflammation, such as tumor necrosis factor (TNF), and the use of biologics that block TNF have been shown to somewhat reduce fatigue. But a new study published online in the journal Rheumatology quantifies just how stubborn RA-related fatigue is – even when the disease itself is well controlled with an anti-TNF medication – and characterizes which patients are most likely to beat it.
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Rheumatoid Arthritis Flares Management Control

Get and Keep Control of Your Rheumatoid Arthritis

When arthritis is active and painful, you have a constant reminder and strong incentive to take your medications. But when your disease is under control, it may be easy to forget a dose or two or you may even be tempted to stop taking your medication altogether. But doing so is not a good idea. The way you are feeling – particularly when you are on medication – is not always an indication of whether there is underlying disease activity. Stopping your medication could cause your disease to flare, resulting in the irreparable joint damage your doctor was aiming to prevent when prescribing medications in the first place.
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Rheumatoid Arthritis Remission Obesity

New Research: Obesity May Reduce the Chance of RA Remission by as Much as Half

People with rheumatoid arthritis (RA) who are obese are less likely to achieve disease remission than their non-obese counterparts, according to a meta-analysis published in May in Arthritis Care and Research. The review also found that obesity was associated with higher levels of disease activity and pain, suggesting excess weight may negatively affect overall outcomes in RA. This meta-analysis supports earlier research, including a study presented at the 2015 annual meeting of the American College of Rheumatology.
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RA Remission Overweight

Being Overweight Can Hurt Rheumatoid Arthritis Remission

If you have a few – or a lot – of pounds to lose, you know that carrying excess weight around can stress your painful or fragile joints. But research shows that the mechanical effects of weight are just part of the problem.

Fat itself releases chemicals including tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) that promote inflammation. These chemicals may not only increase the risk of developing some forms of arthritis, but they may also increase arthritis severity or make it harder to control.

In fact a study presented at the 2015 annual meeting of the American College of Rheumatology found that for people with early rheumatoid arthritis (RA), being overweight or obese can reduce the chance of achieving sustained remission.
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Gut Bacteria Microbes Rheumatoid Arthritis

Gut Bacteria: A Potential Game Changer for Rheumatoid Arthritis

You share your body with trillions of microbes – many of them beneficial bacteria living in your intestinal tract. Collectively called the microbiome, these bugs influence health and disease through complex interactions with your immune system. Often, their role is protective, guarding against pathogens and inflammation. But increasingly strong evidence suggests that disruptions in the microbial ecosystem may cause or contribute to many chronic diseases, including rheumatoid arthritis (RA).

Jose Scher, MD, a rheumatologist at New York University Langone Medical Center, studies the connection between intestinal bugs and arthritis. He thinks the overgrowth of normally benign bacteria called Prevotella – which are far more abundant in people with untreated RA – may trigger an inflammatory response that targets the joints. It’s also possible Prevotella crowds out beneficial bacteria that keep inflammation in check. Either way, Scher is confident there’s a connection between the microbiome and arthritis.
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Rheumatoid Arthritis Outcomes Lifestyle

Outlook Brighter For People With Rheumatoid Arthritis

People with rheumatoid arthritis (RA) are likely to have a much better quality of life today than they did two decades ago. Researchers in the Netherlands observed more than 1,100 patients diagnosed with RA between 1990 and 2011. They attribute the gains to earlier diagnosis, more aggressive medications and a greater emphasis on overall well-being. Their findings were published in Arthritis Care & Research in 2014.

Lead author Cecile Overman, a postdoctoral researcher at Utrecht University in the Netherlands, says she and her colleagues wanted to determine if improved treatments over the last 20 years led to better physical and psychological health for RA patients. Continue reading Outlook Brighter For People With Rheumatoid Arthritis