Detecting rheumatoid arthritis

The Use of Imaging Scans in the Detection and Monitoring of RA

For decades, X-ray images have been used to help detect rheumatoid arthritis (RA) and to monitor for the progression of bone damage. In early RA, however, X-rays may appear normal although the disease is active – making the films useful as a baseline but not much help in getting a timely diagnosis and treatment.

Enter modern imaging techniques, including ultrasound and magnetic resonance imaging (MRI), which can reveal early, non-bony signs of RA that are invisible on X-ray.

“Both MRI and ultrasound are more sensitive at detecting bone erosion than X-ray. In addition, they also reveal inflammation, which we could not see directly before and had to rely on blood tests and using our fingers to feel the joints,” says rheumatologist Philip Conaghan, MD, PhD, professor of musculoskeletal medicine at the University of Leeds and president of the International Society for Musculoskeletal Imaging in Rheumatology.

That capability has become increasingly important with the development of ways to slow the RA disease process, before serious bone and joint damage occurs, using disease-modifying antirheumatic drugs (DMARDs), including biologics.

Both ultrasound and MRI can detect synovitis, inflammation of the lining of the joints, and tendon abnormalities. In addition, MRI detects areas of increased fluid (edema) in bone marrow that is a predictor for the development of bony erosions.

“I will send a patient for an MRI evaluation if the patient has multiple swollen and tender joints, normal X-rays, and a combination of normal and abnormal lab tests for inflammation. If there is bone marrow edema and bony erosions not seen on X-ray I’ll treat them more aggressively,” says Orrin Troum, MD, clinical professor of medicine at the Keck School of Medicine/University of Southern California.

While musculoskeletal MRI is quite expensive and requires an experienced radiologist to read, rheumatologists often have access to power Doppler ultrasound in their offices – used most frequently to guide joint aspirations and injections. Many rheumatologists are able to add ultrasound to their physical exam, but quantifiable measures of what distinguishes RA from normal on ultrasound (or how many joints need to be examined) have been lacking.

In research presented at the American College of Rheumatology (ACR) annual meeting in November 2012, researchers from Brazil looked at how ultrasound measurements taken in small, medium, and large joints could help physicians diagnose RA. For most joints, they were able to quantify a level of change that clearly distinguished RA patients from controls. Wrist measurements were the most valuable, with hip measurements the least help.

“Ultrasound is a very important imaging tool for RA because it is readily available in the office and you can scan many joints,” says lead researcher Flàvia Machado, MD, of the Universidade Federal of São Paulo.

However valuable, Machado cautions that ultrasound is not a solo diagnostic test for rheumatoid arthritis.

“You can see the same bone erosion and synovial lining changes in other rheumatic diseases, such as lupus and psoriatic arthritis (and also in asymptomatic volunteers), so the clinical history and physical examination is still important, with careful evaluation of the pattern of joint involvement and some blood tests to make the diagnosis,” says Dr. Machado.

Is Your Treatment Working?

In recent years, there has been increasing emphasis on using objective scores to monitor disease activity and decide when and if you need a change in treatment to bring RA under control. Although not always needed, ultrasound and MRI can help with those decisions.

“If your joints are tender and swollen and levels of inflammatory markers are elevated, your doctor doesn’t need modern imaging to know you aren’t doing well and it’s time to adjust your treatment,” says Dr. Conaghan.

For tracking joint damage, plain X-rays are still useful if your doctor can examine changes in your films over time, Dr. Conaghan adds.
Surprisingly, patients who seem to be doing well on a treatment may benefit most from modern imaging.

“After several months on a DMARD or biologic, a patient may be asymptomatic but you can tell the disease is not under control if you still see a thickened synovial lining with power Doppler,” says Dr. Machado.

Because inflammation doesn’t entirely disappear even on the best therapy, a number of large studies are currently tracking patients’ progress over time to help determine what a “safe” level of imaging-visualized inflammation would be.. “These studies should also help us understand how to use these modern tools in everyday practice,” says Dr. Conaghan.

On a different research front, the biggest impact of modern imaging may be in streamlining clinical trials of new treatments.

Traditionally, the key indicator of a drug’s value is whether it limits joint damage on X-ray. At the ACR meeting in November 2012, Dr. Troum and colleagues presented validation by Systematic Literature Review that specific MRI findings could be used as indicators of RA damage in wrist and hand joints, finding the most support for MRI-visualized synovitis, bone marrow edema, and erosions.

“If MRI can accurately predict at 3 months what an X-ray will show in one or two years, that can cut the number of patients and the amount of time needed to test a new drug,” says Dr. Troum.

Access to Modern Imaging

The use of ultrasound in rheumatology practice was first widely adopted in Europe but is now gaining ground in the United States. In November 2012, the American College of Rheumatology published a report on reasonable uses of ultrasound in clinical practice. By reasonable, they mean that the health benefits exceed possible negative consequences by a wide margin (not taking cost into consideration).

Among multiple uses, the ACR panel endorsed applying ultrasound to the diagnosis and monitoring of RA in many joints, but they were clear that the technology is not a mandatory component of rheumatology practice. Recommendations on the use of MRI in RA are anticipated in 2013.

Both MRI and ultrasound are more expensive than X-rays. Medicare and several private insurers allow MRI or ultrasound to be used in the evaluation of extremity pain, not specifically to diagnose RA.

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