What if injured joints could heal themselves before they develop osteoarthritis (OA)? Dr. James Martin’s current 3-year Arthritis Foundation-funded project, “Engineering Endogenous Cartilage Repair,” is trying to do just that- find ways to help joints heal before developing OA.
Dr. Martin and his team use special goats that have defects in areas of the thigh bones and cartilage, just above the knee. This closely mimics knee injuries that are seen in humans. The defects are surgically repaired with a hydrogel matrix that contains two important ingredients: repair cell attractant and growth factor. The repair cell attractant causes repair cells, called chondrogenic progenitor cells (CPCs), to migrate into the hydrogel. CPCs naturally occur in the cartilage. The growth factor, which is time-released over 10 days, causes the CPCs in the hydrogel to multiply and repair the injury with new cartilage.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. James Martin
Close to 200 patients, FDA staff, industry leaders, members of the media and academic personnel listened or participated in the groundbreaking Osteoarthritis Patient-Focused Drug Development meeting on March 8. The meeting was a forum for OA patients to share their experiences with the disease and talk about the signs and symptoms that matter most to them.
Continue reading Highlights from 2017 Osteoarthritis Patient-Focused Drug Development Meeting
Last year, the Arthritis Foundation cosponsored the Accelerating Osteoarthritis (OA) Clinical Trials Workshop with the US Food and Drug Administration (FDA). The focus of the workshop aimed at identifying ways to get new diagnostics & treatments to clinics faster for the arthritis community. Important key takeaways from the workshop included a focus on patients – how they need to be more involved in the scientific discovery process and that scientists should consider their needs and wants in designing clinical trials.
Continue reading Arthritis Foundation to Host Meeting for Osteoarthritis Patients to Share their Stories with the FDA
Earlier this year, the Arthritis Foundation awarded nearly $5.5 million in scientific research funding to 11 individuals we believe showed the greatest promise of achieving a faster cure for one or more types of arthritis. These 11 scientists are working on a wide range of projects all over the US – and we want to share their stories and projects with you. These are some of the brightest minds in scientific and arthritis research and they are working hard to find innovative solutions and a cure many types of arthritis. Throughout this series, we will meet each group of researchers and explain the remarkable projects they are working on.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Hongsik J. Cho