In February, we reported on Dr. Farshid Guilak’s current Arthritis Foundation-funded trailblazing project, “Engineering New Biologic Therapies for Arthritis.”
On May 9, Dr. Guilak’s work will be published in the journal Stem Cell Reports. The paper, entitled “Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs,” describes the research team’s method of engineering (reprogramming) stem cells to become “smart stem cells” that will sense inflammation and deliver biologic drugs where they are most needed. The smart stem cells-biologic drug combination is then injected into an arthritic joint.
Continue reading Arthritis Foundation Investigator Developing Arthritis Vaccine
If you have osteoporosis you’ve probably heard of, and may have been treated with, a class of drugs that are used to prevent and treat bone loss: bisphosphonates. Dr. Tuhina Neogi and her research team are using new methods to look at how the long-term effects of using these drugs may be related to the progression of knee osteoarthritis (OA).
Dr. Neogi’s 2-year Arthritis Foundation-funded project, “Bisphosphonate Effects in Knee Osteoarthritis,” is looking at the relationship of bisphosphonate treatment and the structural changes in the knee associated with OA progression. To do this, Dr. Neogi and her team are looking at how knee joint space width, three-dimensional (3D) bone shape, and bone marrow lesions change in OA patients over time.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Tuhina Neogi
What do skin and cartilage have in common? It depends on who you ask. Dr. Veronique Lefebvre, a researcher at Cleveland Clinic Lerner Research Institute, is currently working on a 2016 foundation-funded project called “Quality-by-Design approach to create articular cartilage from pluripotency” that connects the dots between skin and cartilage. Dr. Lefebvre and her team are developing a protocol that starts with skin cells and ends with knee cartilage.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Veronique Lefebvre
Dr. Jose U. Scher, a current Arthritis Foundation-funded investigator, has been looking at the relationship between bacteria and inflammatory diseases for more than 10 years. Dr. Scher’s current Arthritis Foundation funded project, “Pan-Microbiome in At-Risk Subjects and New-Onset Rheumatoid Arthritis (RA),” looks at the relationship of bacteria (or “microbiome” in the mouth, lungs, and intestines) and the development of RA.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Jose Scher
Research on bacteria that live within our bodies has progressed in recent years and is gaining respect in the scientific community. Most of these bacteria live in our gut, and scientists think they shape our health in a number of ways – some good and some bad. Dr. Virginia Kraus is currently researching bacteria in her 2-year Arthritis Foundation-funded project, “The Role of Low-Grade Endotoxemia in Osteoarthritis.” Her project looks at one molecule made by harmful bacteria.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Virginia Kraus
Many of us go to multiple doctors’ appointments throughout the year. Between those appointments, work, family life and other things it can be hard to process and remember the information your doctor tells you. One of our funded researchers, Dr. Delesha Carpenter is looking at how well Rheumatoid Arthritis (RA) patients recall information about newly prescribed DMARDs – disease-modifying antirheumatic drugs. Her 3-year Arthritis Foundation funded research project, called “Understanding how RA patients process conflicting information about DMARDs”, was recently presented at the 2016 ACR Annual Meeting & Conference in November.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Delesha Carpenter
In July, we reported on Dr. Farshid Guilak’s remarkable breakthrough in orthopedic and osteoarthritis research. That research found a way to grow new cartilage on a hip joint shaped scaffold, using stem cells. His current Arthritis Foundation-funded project, “Engineering New Biologic Therapies for Arthritis,” is just as trailblazing.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Farshid Guilak
The third part of our researcher spotlight series is with Dr. Markus Wimmer, Associate Chairman of the Department of Orthopedics and Director of Human Motion Analysis and Tribology at Rush University Medical Center in Chicago, IL. Dr. Wimmer is one of 11 researchers to receive funding in early 2016 for his innovative research project, which uses mobile technology to show how a non-invasive treatment can improve health outcomes for people with osteoarthritis (OA). Dr. Wimmer’s 2 year research project is called “Augmented Feedback Using Pressure Detecting Insoles to Reduce Knee Loading”. The purpose of his research is to look at the use of a pressure based insole to train the OA patient to walk in a way that will reduce pressure in the knees. Reducing knee joint pressure loads may help reduce pain and disease progression.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Markus Wimmer
In August, we brought you our first investigator spotlight on Dr. Cho, one of our 11 researchers to receive funding for scientific research earlier this year. We’ve chosen the brightest minds in the field and the projects they are working on are truly innovative. Today, we are spotlighting another investigator to learn more about his project.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Herb Sun