Tag Archives: arthritis research updates

dr nora singer - banner

Researchers on the Path to a Cure – Spotlight on Dr. Nora Singer

As an organization, we have always supported and encouraged the active involvement of patients in their own care. Patient perspectives matter greatly when it comes to decisions being made about health care. Their voices are vital in the clinical research process as new medications are being developed and tested.

Patient perspectives play a large role in Dr. Nora Singer’s 3-year Arthritis Foundation-funded project – “Cell-based therapy in systemic onset JIA (sJIA) refractory to conventional “c” and biological “b” DMARDs”. Her project uses stem cells derived from adult cells that are designed to “reset” the immune system. The study will compare the safety and effectiveness of the stem cell treatment to conventional and biological disease-modifying antirheumatic drugs (DMARDs). Currently, stem cell therapy is experimental in the U.S. and regulated by the U.S. Food and Drug Administration (FDA), but is less regulated in other countries.

Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Nora Singer

dr richard loeser jr - arthritis research

Researchers on the Path to a Cure – Spotlight on Dr. Richard F. Loeser, Jr

“You are what you eat” is a phrase we often hear. But how true is it? Dr. Richard F. Loeser, Jr. and his research team are looking at the role of diet in their Arthritis Foundation-funded project “The Role of the Microbiome in Metabolic Osteoarthritis (OA)”.

Different factors play into why a person develops OA, including aging, injury, and being overweight. Diet plays an important role. What you eat can help influence what bacteria (or microbiota) live in your digestive track (gut). This, in turn, can influence what chemicals are released into your body. A healthy gut generally has a more diverse collection of helpful microbiota, while a microbial imbalance can lead to disease.

Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Richard F. Loeser, Jr

delivering on discovery

Researchers on the Path to a Cure – Spotlight on Dr. Hongsik Cho

Big things come in small packages, and Dr. Hongsik Cho is very familiar with this phenomenon. When we first introduced Dr. Cho in August 2016, he was beginning work on his 2-year Arthritis Foundation-funded project, “A Novel Method of Detecting and Treating Early PTOA Using Smart Nanosome”.  He and his team are studying two things: a new drug and a new drug delivery system.  The drug, called TPCA-1, works to prevent inflammation caused by post-traumatic osteoarthritis (PTOA).  The drug delivery system uses small packets called nanosomes that contain TPCA-1 and a fluorescent dye that illuminates the nanosomes’ path once injected into mice.

Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Hongsik Cho