Why is my immune system attacking my joints? What is the cause? If you have rheumatoid arthritis (RA), this is something you have probably wondered at some point. It’s something Dr. Edward Doherty has wondered as well, and is currently studying. Dr. Doherty and his co-investigator, Dr. Pathricia Tilstam are studying key cells that drive inflammation in their 2-year Arthritis Foundation-funded project, “MIF/CD74 signaling as a new candidate for immunotherapy of rheumatoid arthritis”. With autoimmune disorders like RA, something triggers the immune system to malfunction and attack healthy cells, causing inflammation and disease. Dr. Doherty and Dr. Tilstam are looking for some of the triggers to help develop more effective treatments to stop progression and joint destruction.
It’s no secret that obesity is associated with a higher risk of developing rheumatic diseases and worse outcomes. Three new studies, presented recently at the 2017 Annual Meeting of the American College of Rheumatology, characterize in greater detail the harmful effects of excess weight in people who have rheumatoid arthritis (RA) or axial spondyloarthropathy (axSpA).
Last week at the Conference of Champions, Andrea Avery, author and Arizona-based Foundation volunteer, shared her gripping story, intertwining her love for piano and the reality of her arthritis. Beyond sharing her personal story with hundreds of volunteers in Phoenix, she also met and performed with her inspiration, Byron Janis, master and renowned pianist. See below for an excerpt from her book, Sonata: A Memoir of Pain and the Piano.
Venom can kill, but this research proves it could help do the opposite. More specifically, some chemicals found in venom could act as a treatment for disease. These chemicals come from a deadly reptile, but with the help of Dr. Christine Beeton, venom might be able to better the lives of multitudes of people.
Dr. Beeton and her research team are looking at the chemicals found in scorpion venom as a source of potential treatment for autoimmune diseases like rheumatoid arthritis (RA).
Every day, scientists work toward the advancement of rheumatoid arthritis (RA)treatment. And Dr. C. Michael Stein has made an exciting new discovery that could help these advancements along and predict how specific treatments will work.
Dr. Stein is looking at small molecules that have the potential to cause big problems. His 5-year Arthritis Foundation-funded project, “Extracellular small RNAs in rheumatoid arthritis,” is looking at how small molecules of ribonucleic acid (RNA) in the blood may be markers for different diseases.
Earlier this year, we awarded funding to six scientists for projects submitted that show remarkable innovations and steps towards finding a cure for arthritis and related diseases. For the first time, we included patient input in selecting the projects that showed the most promise and meant the most to them.
If you suffer from rheumatoid arthritis (RA), Dr. Salah Ahmed’s research project may be just your cup of (green) tea! Dr. Ahmed’s 2014 Innovative Research Grant project, “Mechanism of Mcl-1 regulation in RA by EGCG”, looked at the effects of an anti-inflammatory molecule found in green tea (epigallocatechin-3-gallate or EGCG) on a protein (Mcl-1) found in RA joints.
The Food and Drug Administration (FDA) recently approved the biologic drug sarilumab (Kevzara) for the treatment of rheumatoid arthritis (RA). Sarilumab blocks a protein called interleukin-6 (IL-6), which plays a key role in many inflammatory diseases, including RA. It’s the second IL-6 inhibitor to receive FDA approval for RA; the other, tocilizumab (Actemra), got the nod in 2010.
Continue reading FDA OKs a New Biologic for RA
Living Your Yes with RA is a personalized goal-setting event brought to you by the Arthritis Foundation. This free forum gives you the opportunity to learn ways that can help you say Yes more than No, despite the challenges of living with rheumatoid arthritis (RA). You’ll get expert advice from a local rheumatologist plus guidance on setting goals that can help you live life to the fullest. Let us help you manage your RA, as well as communicate effectively with your own doctor.
Continue reading Coming this Fall – Living Your Yes With RA, A Personalized Goal-Setting Event
Up to half of patients treated with the arthritis drug hydroxychloroquine (Plaquenil) are prescribed more than the recommended maximum amount, according to new research. In separate studies, Canadian and U.S. researchers found that 30 to 50 percent of patients didn’t receive the dose outlined in treatment guidelines; a smaller percentage didn’t get recommended eye exams.
Continue reading Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk