Category Archives: Osteoarthritis

2017 Osteoarthritis Patient-Focused Drug Development Meeting

Highlights from 2017 Osteoarthritis Patient-Focused Drug Development Meeting

Close to 200 patients, FDA staff, industry leaders, members of the media and academic personnel listened or participated in the groundbreaking Osteoarthritis Patient-Focused Drug Development meeting on March 8. The meeting was a forum for OA patients to share their experiences with the disease and talk about the signs and symptoms that matter most to them.
Continue reading Highlights from 2017 Osteoarthritis Patient-Focused Drug Development Meeting

Arthritis Research Dr. Virginia Kraus

Researchers on the Path to a Cure – Spotlight on Dr. Virginia Kraus

Research on bacteria that live within our bodies has progressed in recent years and is gaining respect in the scientific community. Most of these bacteria live in our gut, and scientists think they shape our health in a number of ways – some good and some bad. Dr. Virginia Kraus is currently researching bacteria in her 2-year Arthritis Foundation-funded project, “The Role of Low-Grade Endotoxemia in Osteoarthritis.” Her project looks at one molecule made by harmful bacteria.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Virginia Kraus

Osteoarthritis Drug Development Meeting

Arthritis Foundation to Host Meeting for Osteoarthritis Patients to Share their Stories with the FDA

Last year, the Arthritis Foundation cosponsored the Accelerating Osteoarthritis (OA) Clinical Trials Workshop with the US Food and Drug Administration (FDA). The focus of the workshop aimed at identifying ways to get new diagnostics & treatments to clinics faster for the arthritis community. Important key takeaways from the workshop included a focus on patients – how they need to be more involved in the scientific discovery process and that scientists should consider their needs and wants in designing clinical trials.
Continue reading Arthritis Foundation to Host Meeting for Osteoarthritis Patients to Share their Stories with the FDA

Dr. Farshid Guilak

Researchers on the Path to a Cure – Spotlight on Dr. Farshid Guilak

In July, we reported on Dr. Farshid Guilak’s remarkable breakthrough in orthopedic and osteoarthritis research. That research found a way to grow new cartilage on a hip joint shaped scaffold, using stem cells. His current Arthritis Foundation-funded project, “Engineering New Biologic Therapies for Arthritis,” is just as trailblazing.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Farshid Guilak

Dr. Wimmer Arthritis Foundation research

Researchers on the Path to a Cure – Spotlight on Dr. Markus Wimmer

The third part of our researcher spotlight series is with Dr. Markus Wimmer, Associate Chairman of the Department of Orthopedics and Director of Human Motion Analysis and Tribology at Rush University Medical Center in Chicago, IL. Dr. Wimmer is one of 11 researchers to receive funding in early 2016 for his innovative research project, which uses mobile technology to show how a non-invasive treatment can improve health outcomes for people with osteoarthritis (OA). Dr. Wimmer’s 2 year research project is called “Augmented Feedback Using Pressure Detecting Insoles to Reduce Knee Loading”. The purpose of his research is to look at the use of a pressure based insole to train the OA patient to walk in a way that will reduce pressure in the knees. Reducing knee joint pressure loads may help reduce pain and disease progression.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Markus Wimmer

heart attack stroke risk celebrex nsaids

Celecoxib: Not So Hard on the Heart?

The recent findings of a huge study may erase some concerns about a pain reliever that has long been saddled with a worrisome reputation: celecoxib (Celebrex). While all nonsteroidal anti-inflammatory drugs (NSAIDs) carry a warning that users have an increased risk for heart attacks and strokes, celecoxib is closely linked to two similar drugs that were taken off the market due to concerns about their cardiovascular safety. However, the new research suggests that celecoxib may not be more dangerous than other NSAIDs, and might even be safer in some important ways. Continue reading Celecoxib: Not So Hard on the Heart?

Dr. Sun Arthritis Foundation research

Researchers on the Path to a Cure – Spotlight on Dr. Herb Sun

In August, we brought you our first investigator spotlight on Dr. Cho, one of our 11 researchers to receive funding for scientific research earlier this year. We’ve chosen the brightest minds in the field and the projects they are working on are truly innovative. Today, we are spotlighting another investigator to learn more about his project.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Herb Sun

Dr. Cho Osteoarthritis Research

Researchers on the Path to a Cure – Spotlight on Dr. Hongsik J. Cho

Earlier this year, the Arthritis Foundation awarded nearly $5.5 million in scientific research funding to 11 individuals we believe showed the greatest promise of achieving a faster cure for one or more types of arthritis. These 11 scientists are working on a wide range of projects all over the US – and we want to share their stories and projects with you. These are some of the brightest minds in scientific and arthritis research and they are working hard to find innovative solutions and a cure many types of arthritis. Throughout this series, we will meet each group of researchers and explain the remarkable projects they are working on.
Continue reading Researchers on the Path to a Cure – Spotlight on Dr. Hongsik J. Cho

Arthritis Research Clinical Trials

Improving the Landscape of Clinical Trials – Together

Did you know there is an organization dedicated to identifying and promoting practices to increase the quality and efficiency of clinical trials? There is! And the Arthritis Foundation is a part of it. The Clinical Trials Transformation Initiative (CTTI) is a public-private partnership cofounded by the FDA and Duke University that exists solely to improve clinical trials. The Arthritis Foundation is part of the steering committee at CTTI, which is made up of representatives from CTTI members across multiple sectors and provides input into decisions about CTTI priorities, projects and recommendations.
Continue reading Improving the Landscape of Clinical Trials – Together

metal on metal hip implant failure

Failure Risks of Metal-on-Metal Hip Implants

Bone loss and subsequent implant failure are well known complications of metal-on-metal (MoM) hip implants. Researchers now think they know why. In an article published recently in the journal Biomaterials, German investigators say metal debris from the implants may affect the body’s ability to form new bone.

A metal-on-metal hip implant consists of a ball and cup made of a cobalt and chromium alloy. Originally developed as a more durable alternative to implants with ceramic or polyethylene (plastic) components, MoM implants proved to be the opposite. In general, they have a much higher failure rate than implants made of other materials – a problem attributed mainly (but not solely) to bone erosion in the hip joint, which leads to the artificial joint loosening and the need for revision surgery.
Continue reading Failure Risks of Metal-on-Metal Hip Implants