dr c michael stein

Researchers on the Path to a Cure – Spotlight on Dr. C. Michael Stein

Every day, scientists work toward the advancement of rheumatoid arthritis (RA)treatment. And Dr. C. Michael Stein has made an exciting new discovery that could help these advancements along and predict how specific treatments will work.

Dr. Stein is looking at small molecules that have the potential to cause big problems.  His 5-year Arthritis Foundation-funded project, “Extracellular small RNAs in rheumatoid arthritis,” is looking at how small molecules of ribonucleic acid (RNA) in the blood may be markers for different diseases.

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arthritis research awardees

Arthritis Patients Help to Select Scientific Projects That Show Promise Towards Finding a Cure for Arthritis

Earlier this year, we awarded funding to six scientists for projects submitted that show remarkable innovations and steps towards finding a cure for arthritis and related diseases. For the first time, we included patient input in selecting the projects that showed the most promise and meant the most to them.

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Winterhoff Scholarship Awardees

Winterhoff Arthritis Scholarship Goes National – Eight 2017 Recipients Announced

Champion of Yes has come to mean different things to different people. To many, it means refusing to let arthritis win – to stand up, push back and say, “Enough is enough. I won’t let arthritis stop me or anyone else from living life to its fullest!”

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no arthroscopy for knee OA

Doctors and Patients Say ‘No’ to Arthroscopy for Arthritis

About 1 million knee arthroscopies are performed each year in the United States, at a cost of more than $3 billion. Now, in new guidelines, an international panel of experts has strongly recommended against the surgery for nearly everyone with “degenerative knee disease.” Degenerative knee disease is another way to refer to knee osteoarthritis (OA), and includes degenerative meniscus tears, trouble with knee movement and sudden onset of pain and swelling. The guidelines were published in the journal BMJ in May.

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dr-ahmed

Researchers on the Path to a Cure – Spotlight on Salah Ahmed

If you suffer from rheumatoid arthritis (RA), Dr. Salah Ahmed’s research project may be just your cup of (green) tea! Dr. Ahmed’s 2014 Innovative Research Grant project, “Mechanism of Mcl-1 regulation in RA by EGCG”, looked at the effects of an anti-inflammatory molecule found in green tea (epigallocatechin-3-gallate or EGCG) on a protein (Mcl-1) found in RA joints.

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arthritis drugs help physical symptoms more than depression

Arthritis Drugs Help Physical Symptoms More Than Disease-Related Depression

Major depression is not uncommon in people with rheumatoid arthritis (RA) – different studies have pegged the number at between 17 percent and 40 percent – but the drugs used to treat RA do little to alleviate depression, according to a systematic review presented at the 2017 British Society for Rheumatology annual conference in Birmingham, United Kingdom.
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10th Annual National Gathering

Highlights from the 10th Annual National Gathering Conference

What a wonderful weekend! The 10th annual National Gathering Conference was held last weekend June 9-11 in Kansas City and what a weekend it was! This year’s conference was particularly special – we celebrated 10 amazing years of this wonderful Gathering which was reflected in the conference theme “10 Years & Growing,” and throughout the conference.

The Gathering was created for adults living with arthritis and rheumatic diseases to gather together and learn from healthcare and patient experts how to live their best life. We all know living with arthritis is difficult, but at the Gathering we learn together how to combat life’s daily challenges.
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Dr. James Martin Arthritis Research

Researchers on the Path to a Cure – Spotlight on Dr. James Martin

What if injured joints could heal themselves before they develop osteoarthritis (OA)? Dr. James Martin’s current 3-year Arthritis Foundation-funded project, “Engineering Endogenous Cartilage Repair,” is trying to do just that- find ways to help joints heal before developing OA.

Dr. Martin and his team use special goats that have defects in areas of the thigh bones and cartilage, just above the knee. This closely mimics knee injuries that are seen in humans. The defects are surgically repaired with a hydrogel matrix that contains two important ingredients: repair cell attractant and growth factor. The repair cell attractant causes repair cells, called chondrogenic progenitor cells (CPCs), to migrate into the hydrogel. CPCs naturally occur in the cartilage. The growth factor, which is time-released over 10 days, causes the CPCs in the hydrogel to multiply and repair the injury with new cartilage.
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Akylosing Spodylitis Treatment

FDA OKs a New Biologic for RA

The Food and Drug Administration (FDA) recently approved the biologic drug sarilumab (Kevzara) for the treatment of rheumatoid arthritis (RA). Sarilumab blocks a protein called interleukin-6 (IL-6), which plays a key role in many inflammatory diseases, including RA. It’s the second IL-6 inhibitor to receive FDA approval for RA; the other, tocilizumab (Actemra), got the nod in 2010.
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